HALOZYME REPORTS THIRD QUARTER 2026 RESULTS AND RAISES FULL YEAR 2026 FINANCIAL GUIDANCE

PR Newswire

SAN DIEGO, Nov. 5, 2026

Total Revenue Increased 39% YOY to $493 million
Royalty Revenue Increased 44% YOY to $341 million

Raising 2026 Financial Guidance Ranges:
Total Revenue of $1.860 - $1.925 billion, YOY Growth of 33% - 38%
Royalty Revenue of $1.235 - $1.255 billion, YOY Growth of 42% - 45%
Adjusted EBITDA of $1.240 - $1.290 billion, YOY Growth of 89% - 96%1
Non-GAAP Diluted EPS of $8.75 - $9.05, YOY Growth of 111% - 118%1

Expanded ENHANZE® Collaboration Agreements with Three Current Partners

Three ENHANZE® Programs Advanced into Phase 1 Clinical Development

SAN DIEGO, Nov. 5, 2026 /PRNewswire/ -- Halozyme Therapeutics, Inc. (Nasdaq: HALO) ("Halozyme" or the "Company") today reported its financial and operating results for the third quarter ended September 30, 2026, and provided an update on its recent corporate activities.

"Halozyme delivered another exceptional quarter, with total revenue increasing 39% and royalty revenue growing 44% year-over-year to record levels," said Dr. Helen Torley, President and Chief Executive Officer. "In and post the quarter, we have achieved multiple milestones that expand our opportunity and diversify our revenue. During the quarter, we expanded our agreements with argenx and Incyte to include additional targets to be evaluated with ENHANZE. In October, we also signed an expanded agreement with Johnson & Johnson for one additional target. Three ENHANZE programs, one each with Pfizer, Incyte and argenx advanced into Phase 1 clinical development, bringing our total products in development to twelve."

Dr. Torley continued, "In October, we also achieved an important victory in protecting our intellectual property. The Dutch specialized patent court found that Merck is infringing one of our MDASE patents and granted an injunction prohibiting the launch of Keytruda Qlex in multiple European markets.  Our commitment to protecting the value of our innovations, growing royalties, continued partner expansion and growing pipeline demonstrates the power of Halozyme's compounding platform engine and positions us to deliver durable revenue well into the next decade."

"Based on our strong financial performance this quarter, we are pleased to be able to raise our guidance for the full year 2026," said Darren Snellgrove, Executive Vice President and Chief Financial Officer. "We also further strengthened our financial position with the successful completion of our $1.5 billion convertible notes, which enhances our flexibility to execute our disciplined capital allocation strategy. We completed $400 million in share repurchases this year while continuing to invest in our highest-return organic opportunities and maintaining a clear path to retire our remaining 2027 and 2028 notes at maturity. With our strong cash generation, we remain focused on capital deployment to maximize long-term value creation."

Recent and Third Quarter Corporate Highlights:

Recent Partner Highlights:

Third Quarter Partner Highlights:

Third Quarter 2026 Financial Highlights:

Financial Outlook for 2026

The Company is raising its 2026 financial guidance ranges, which were last updated on August 6, 2026.

For the full year 2026, the Company expects:

Table 1. 2026 Financial Guidance



Previous Guidance Range


New Guidance Range

Total Revenue


$1.835 to $1.910 billion


$1.860 to $1.925 billion

Royalty Revenue


$1.220 to $1.245 billion


$1.235 to $1.255 billion

Adjusted EBITDA1


$1.225 to $1.280 billion


$1.240 to $1.290 billion

Non-GAAP Diluted EPS1


$8.65 to $9.00


$8.75 to $9.05

1 EBITDA, Adjusted EBITDA and Non-GAAP Diluted EPS are Non-GAAP financial measures. See "Note Regarding Use of Non-GAAP Financial Measures" below for an explanation of these measures. Reconciliations between GAAP reported and Non-GAAP financial information for actual results are provided at the end of this earnings release.

Webcast and Conference Call

Halozyme will host its Quarterly Update Conference Call for the third quarter ended September 30, 2026 today, Thursday, November 5, 2026, at 1:30 p.m. PT/4:30 p.m. ET. The conference call may be accessed live with pre-registration via link: https://events.q4inc.com/analyst/811361061?pwd=qhqAVQ9L. The call will also be webcast live through the "Investors" section of Halozyme's corporate website and a recording will be made available following the close of the call. To access the webcast and additional documents related to the call, please visit Halozyme.com.

About Halozyme

Halozyme is a biopharmaceutical company advancing disruptive solutions to improve patient experiences and outcomes for emerging and established therapies. As the innovators of ENHANZE® drug delivery technology with the proprietary enzyme rHuPH20, Halozyme's commercially-validated solution is used to facilitate the subcutaneous delivery of injected drugs and fluids, with the goal of reducing treatment burden and improving convenience. ENHANZE® has touched more than one million patient lives through ten commercialized products across over 100 global markets and is licensed to leading pharmaceutical and biotechnology companies including Roche, Takeda, Pfizer, Janssen, AbbVie, Eli Lilly, Bristol-Myers Squibb, argenx, ViiV Healthcare, Chugai Pharmaceutical, Acumen Pharmaceuticals, Merus N.V., GSK, and Incyte.

Halozyme expanded its drug delivery technology portfolio to develop partner products using Hypercon™ and Surf Bio's hyperconcentration technology, recently renamed as Aerocon™. Hypercon™ is microparticle technology with the potential to set a new standard in hyperconcentration of drugs and biologics by reducing injection volume for the same dosage and enabling administration in at-home and healthcare-provider settings. The addition of Aerocon™ polymer-based hyperconcentration technology may further broaden the range of biologics that can be delivered subcutaneously. Together, we believe Hypercon™ and Aerocon™ technology complement ENHANZE® by enabling creation and delivery of highly concentrated biologics. The Hypercon™ technology has been licensed to leading biopharmaceutical partners, including Janssen, Eli Lilly, argenx, Vertex Pharmaceuticals, and Oruka Therapeutics.

Halozyme also develops, manufactures and commercializes drug-device combination products using advanced auto-injector technologies designed to improve convenience, reliability and tolerability, enhancing patient comfort and adherence. The Company has two proprietary commercial products, Hylenex® and XYOSTED®, partnered commercial products and ongoing development programs with Teva Pharmaceuticals and McDermott Laboratories Limited, an affiliate of Viatris Inc.

Halozyme is headquartered in San Diego, CA, with offices in Ewing, NJ; Minnetonka, MN; and Boston, MA. Minnetonka is also the site of its operations facility.

For more information, visit www.halozyme.com and connect with us on LinkedIn.

Note Regarding Use of Non-GAAP Financial Measures

In addition to disclosing financial measures prepared in accordance with U.S. generally accepted accounting principles ("GAAP"), this press release and the accompanying tables contain certain Non-GAAP financial measures. The Company reports earnings before interest, taxes, depreciation, and amortization ("EBITDA"), adjusted EBITDA, Non-GAAP diluted earnings per share, Non-GAAP diluted shares, and guidance with respect to those measures, in addition to, and not as a substitute for, or superior to, financial measures calculated in accordance with GAAP. The Company calculates EBITDA excluding interest, taxes, depreciation and amortization. The Company calculates adjusted EBITDA excluding one-time items, if any, such as changes in contingent liabilities, inventory adjustments, impairment charges, transaction costs for business combinations and share-based compensation acceleration expenses and intellectual property litigation costs. The Company calculates Non-GAAP diluted earnings per share excluding share-based compensation expense, amortization of debt discounts, intangible asset amortization, one-time items, if any, such as changes in contingent liabilities, inventory adjustments, impairment charges, transaction costs for business combinations and share-based compensation acceleration expenses, intellectual property litigation costs, inducement expenses related to convertible notes, and certain adjustments to income tax expense. The Company calculates Non-GAAP diluted shares excluding the dilutive impact of convertible notes which is used in calculating Non-GAAP diluted earnings per share. Reconciliations between GAAP and Non-GAAP financial measures are included at the end of this press release. The Company does not provide reconciliations for forward-looking adjusted measures to GAAP due to the inherent difficulty in forecasting and quantifying certain amounts that are necessary for such reconciliation, including adjustments that could be made for changes in share-based compensation expense and the effects of any discrete income tax items. For the same reasons, the Company is unable to address the probable significance of the unavailable information. The Company provides Non-GAAP financial measures that it believes will be achieved; however, it cannot accurately predict all of the components of the adjusted calculations and the GAAP measures may be materially different than the Non-GAAP measures.

The Company evaluates other items of income and expense on an individual basis for potential inclusion in the calculation of Non-GAAP financial measures and considers both the quantitative and qualitative aspects of the item, including (i) its size and nature, (ii) whether or not it relates to the Company's ongoing business operations and (iii) whether or not the Company expects it to occur as part of the Company's normal business on a regular basis. Non-GAAP financial measures do not have any standardized meaning and are therefore unlikely to be comparable to similarly titled measures presented by other companies. These Non-GAAP financial measures are not meant to be considered in isolation and should be read in conjunction with the Company's consolidated financial statements prepared in accordance with GAAP, and are not prepared under any comprehensive set of accounting rules or principles. In addition, from time to time in the future there may be other items that the Company may exclude for purposes of its Non-GAAP financial measures, and the Company may in the future cease to exclude items that it has historically excluded for purposes of its Non-GAAP financial measures.

The Company considers these Non-GAAP financial measures to be important because they provide useful measures of the operating performance of the Company, exclusive of factors that do not directly affect what the Company considers to be its core operating performance, as well as unusual events. The Non-GAAP measures also allow investors and analysts to make additional comparisons of the operating activities of the Company's core business over time and with respect to other companies, as well as assessing trends and future expectations. The Company uses Non-GAAP financial information in assessing what it believes is a meaningful and comparable set of financial performance measures to evaluate operating trends, as well as in establishing portions of our performance-based incentive compensation programs.

Safe Harbor Statement

In addition to historical information, the statements set forth in this press release include forward-looking statements including, without limitation, statements concerning the Company's financial performance (including the Company's expected financial outlook for 2026) and expectations for future growth, profitability, revenue durability and diversity, total revenue, royalty revenue, royalty revenue duration, EBITDA, Adjusted EBITDA, and non-GAAP diluted earnings-per-share, and shareholder value and retirement of outstanding debt. These forward-looking statements also include statements regarding the injunction issued by the specialized Dutch patent court of the Hague and other findings of the court mentioned in this press release, the Company's potential receipt of upfront payments and payments associated with achievement of certain development, regulatory and sales-based milestones, and royalties on sales of commercialized products from our collaboration agreements. Forward-looking statements regarding the Company's ENHANZE® drug delivery technology may include the possible benefits and attributes of ENHANZE®, its potential application to aid in the dispersion and absorption of other injected therapeutic drugs and facilitating more rapid delivery and administration of higher volumes of injectable medications through subcutaneous delivery including its potential application with antibody drug conjugates. Forward-looking statements regarding the Company's Hypercon™ and Aerocon™ technologies include the possible benefits and attributes of these technologies, including the potential to reduce injection volume for the same dosage of drugs and biologics and possibly enabling administration in at‑home and healthcare‑provider settings and statements concerning certain other potential benefits of these technologies including facilitating administration of injectable medications through subcutaneous delivery by enabling creation and delivery of highly concentrated biologics and potentially lowering the treatment burden, easing treatment access and improving the treatment experience for patients. Forward-looking statements regarding the Company's business may include potential growth and receipt of royalty and milestone payments driven by our partners' development and commercialization efforts, potential new clinical trial study starts and advancement of partnered development programs, regulatory submissions and product launches, the size and growth prospects of our partners' drug franchises, potential new or expanded collaborations and collaborative targets, and potential approvals of new partnered or proprietary products, and the potential timing of these events. These forward-looking statements are typically, but not always, identified through use of the words "expect," "believe," "enable," "may," "will," "could," "intends," "estimate," "anticipate," "plan," "predict," "probable," "potential," "preliminary," "possible," "should," "continue," and other words of similar meaning and involve risk and uncertainties that could cause actual results to differ materially from those in the forward-looking statements. Actual results could differ materially from the expectations contained in these forward-looking statements as a result of several factors, including uncertainties concerning future matters such as unexpected changes in market conditions, changes in domestic and foreign business, changes in the competitive environment in which the Company operates, judicial decisions related to the injunction and other judicial findings mentioned in this press release, unexpected early expiration or termination of the patent terms for the Company's drug delivery technologies, unexpected levels of revenues, expenditures and costs, unexpected results or delays in the growth of the Company's business, or in the development, regulatory review or commercialization of the Company's partnered or proprietary products, regulatory approval requirements, unexpected adverse events or patient outcomes and competitive conditions. These and other factors that may result in differences are discussed in greater detail in the Company's most recent Annual Report on Form 10-K and Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission, including under the headings "Risk Factors" and "Management's Discussion and Analysis of Financial Condition and Results of Operations". Except as required by law, the Company undertakes no duty to update forward-looking statements to reflect events after the date of this release.

Contact:
Tram Bui
VP, Investor Relations and Corporate Communications
609-333-7668
tbui@halozyme.com

Halozyme Therapeutics, Inc

Condensed Consolidated Statements of Operations

(Unaudited)

(In thousands, except per share amounts)

 



Three Months Ended


Nine Months Ended



September 30,


September 30,



2026


2025


2026


2025

Revenues









Royalties


$   341,001


$   236,038


$   889,381


$   609,869

Product sales, net


137,328


94,228


397,378


253,779

Revenues under collaborative agreements


14,645


23,998


63,922


81,196

Total revenues


492,974


354,264


1,350,681


944,844

Operating expenses









Cost of sales


82,475


55,242


240,884


150,004

Amortization of intangibles


29,512


17,762


88,536


53,286

Research and development


27,778


17,251


81,002


49,593

Selling, general and administrative


58,240


46,088


173,119


130,064

Total operating expenses


198,005


136,343


583,541


382,947

Operating income


294,969


217,921


767,140


561,897

Other income (expense)









Investment and other income, net


2,172


5,333


6,326


19,042

Inducement expense related to convertible notes


(465)


—


(465)


—

Interest expense


(6,045)


(4,296)


(17,141)


(13,215)

Income before income tax expense


290,631


218,958


755,860


567,724

Income tax expense


43,582


43,733


128,849


109,244

Net income


$   247,049


$   175,225


$   627,011


$   458,480










Earnings per share









Basic


$       2.17


$       1.49


$       5.39


$       3.80

Diluted


$       2.01


$       1.43


$       5.12


$       3.68










Weighted average common shares outstanding









Basic


113,797


117,219


116,389


120,570

Diluted


122,611


122,331


122,349


124,449

 

Halozyme Therapeutics, Inc

Condensed Consolidated Balance Sheets

(Unaudited)

(In thousands)

 



September 30,
2026


December 31,
2025

ASSETS





Current assets





Cash and cash equivalents


$    1,029,988


$      133,820

Marketable securities, available-for-sale


44,399


9,000

Accounts receivable, net and contract assets


525,592


441,273

Inventories


132,613


176,475

Prepaid expenses and other current assets


114,138


64,639

Total current assets


1,846,730


825,207

Property and equipment, net


82,286


82,137

Prepaid expenses and other assets


68,806


53,551

Goodwill


581,732


580,360

Intangible assets, net


892,931


981,467

Restricted cash


861


2,601

Total assets


$    3,473,346


$    2,525,323






LIABILITIES AND STOCKHOLDERS' (DEFICIT) EQUITY





Current liabilities





Accounts payable


$        33,546


$        20,899

Accrued expenses


136,930


156,193

Current portion of long-term debt, net


305,612


—

Total current liabilities


476,088


177,092

Long-term debt, net


2,944,691


2,142,630

Other long-term liabilities


101,466


113,863

Deferred tax liabilities, net


6,340


42,924

Total liabilities


3,528,585


2,476,509






Stockholders' (deficit) equity





Common stock


114


118

Additional paid-in capital


—


12,002

Accumulated other comprehensive loss


2,781


(18,092)

(Accumulated Deficit) Retained earnings


(58,134)


54,786

Total stockholders' (deficit) equity


(55,239)


48,814

Total liabilities and stockholders' (deficit) equity


$    3,473,346


$    2,525,323

 

Halozyme Therapeutics, Inc

GAAP to Non-GAAP Reconciliations

EBITDA

(Unaudited)

(In thousands)

 



Three Months Ended



September 30,



2026


2025

GAAP Net Income


$   247,049


$   175,225

Adjustments





Investment and other income, net


(2,172)


(5,334)

Interest expense


6,045


4,296

Income tax expense


43,582


43,733

Depreciation and amortization


34,199


20,420

EBITDA


328,703


238,340

Adjustments





Transaction costs for business combinations(1)


—


3,871

Intellectual property litigation costs(2)


7,452


6,038

Adjusted EBITDA


$   336,155


$   248,249



(1)

Amount represents incremental costs including legal and advisory fees incurred in association with the acquisition of Elektrofi.

(2)

Adjustment relates to litigation costs incurred by Halozyme in connection with Halozyme's patent infringement litigation against Merck Sharp & Dohme LLC ("Merck"). These charges are excluded because the Company does not believe they are reflective of the Company's ongoing business and operating results.

 

Halozyme Therapeutics, Inc

GAAP to Non-GAAP Reconciliations

Net Income and Diluted EPS

(Unaudited)

(In thousands, except per share amounts)

 



Three Months Ended



September 30,



2026


2025

GAAP Net Income


$   247,049


$   175,225

Adjustments





Inducement expense related to convertible notes


465


—

Share-based compensation


16,802


12,160

Amortization of debt discount


2,220


1,858

Amortization of intangible assets


29,512


17,762

Transaction costs for business combinations(1)


—


3,871

Intellectual property litigation costs(2)


7,452


6,038

Income tax effect of above adjustments(3)


(19,699)


(10,120)

Non-GAAP Net Income


$   283,801


$   206,794






GAAP Diluted EPS


$       2.01


$       1.43

Adjustments





Inducement expense related to convertible notes


0.01


—

Share-based compensation


0.15


0.10

Amortization of debt discount


0.02


0.02

Amortization of intangible assets


0.25


0.15

Transaction costs for business combinations(1)


—


0.03

Intellectual property litigation costs(2)


0.07


0.05

Income tax effect of above adjustments(3)


(0.17)


(0.08)

Non-GAAP Diluted EPS


$       2.39


$       1.72






GAAP Diluted Shares


122,611


122,331

Adjustments





Adjustment for dilutive impact of convertible notes(4)


(3,728)


(2,014)

Non-GAAP Diluted Shares


118,883


120,317


Dollar amounts, as presented, are rounded. Consequently, totals may not add up.

(1)

Amount represents incremental costs including legal and advisory fees incurred in association with the acquisition of Elektrofi.

(2)

Adjustment relates to litigation costs incurred by Halozyme in connection with Halozyme's patent infringement litigation against Merck. These charges are excluded because the Company does not believe they are reflective of the Company's ongoing business and operating results.

(3)

Adjustments relate to taxes for the reconciling items, as well as excess benefits or tax deficiencies from share-based compensation, and the quarterly impact of other discrete items.

(4)

Adjustment made for the dilutive effect of our convertible notes due 2028, 2031 and 2032 when the effect is not the same on a GAAP and Non-GAAP basis for the reporting period.



Halozyme Therapeutics, Inc. Logo. (PRNewsFoto/Halozyme Therapeutics, Inc.)

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SOURCE Halozyme Therapeutics, Inc.